Im sure this will be yet another weird Commander buildaround, but I think Niv-Mizzet, Guildpact mostly wants to hang out in the graveyard waiting to get pulled along by your Lazav, Wearer of Faces, like Weekend at Bernies 2: Guildpact Edition
Discard already suffers from doing nothing on an empty hand, the fact that Duress can still do little on a full hand means you have to be quite careful how you build with Duress and where
The set was first legal for the 2016 World Championship, where many players werent expecting it to have much of an impact
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Hold up, friend
Put that card onto the battlefield and the rest into your graveyard
