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PP1βMYPT1 phosphatase complex and the SCFβTrCP E3 ubiquitin ligase
InChiKey: KZYAHEIPPAPADQ-UHFFFAOYSA-N
[Epub ahead of print] PubMed PMID: 30029697
NMR and surface plasmon resonance biosensor studies confirm COH29 binding to the proposed ligand-binding pocket and offer evidence for assembly blockade of the RRM1-RRM2 quaternary structure
establishing favorable hydrophobic and hydrogen bonding interactions with the protein’s active-site residues
U0126 hostatin A (TSA) PP1βMYPT1 phosphatase complex and theU0126 is a potent and selective non competitive inhibitor of MAP kinase. Inhibits MEK 1 and MEK 2 (IC50 values of 0. 07 and 0. 06 M respectively). Product information CAS Number: 109511 58 2 Molecular Weight: 380. 49 Formula: C18H16N6S2 Synonym: U 0126 Related CAS Number: 1173097 76 1 (U0126 EtOH) Chemical Name: bis({amino[(2 aminophenyl)sulfanyl]methylidene})butanedinitrile Smiles: NC1=CC=CC=C1SC(N)=C(C#N)C(C#N)=C(N)SC1=CC=CC=C1N InChiKey: