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Targeted Degradation of Proteins Localized in Subcellular Compartments by Hybrid Small Molecules
thereby inhibiting receptor phosphorylation and signal transduction and resulting in apoptosis and suppression of proliferation in tumor cells that overexpress these receptors
immunoblotting of protein lysates from C33A-2D2 cells stimulated with SJ000291942 at different times is performed
the pimecrolimusmacrophilin complex then binds to the cytosolic enzyme calcineurin phosphatase
Smiles: CC1=CC=C(C=NNC(=O)C2=CC=CC=C2OC2C=CC=CC=2)O1
AMG 232 Catalog No.:M8600-2 Targeted Degradation of Proteins LocalizedAMG232 is an extremely potent MDM2 inhibitor (SPR KD = 0. 045 nM, SJSA 1 EdU IC50 = 9. 1 nM), with remarkable pharmacokinetic properties and in vivo antitumor activity in the SJSA 1 osteosarcoma xenograft model (ED50 = 9. 1 mg kg). AMG232 is currently under clinical development. Product information CAS Number: 1352066 68 2 Molecular Weight: 568. 55 Formula: C28H35Cl2NO5S Synonym: AMG232 AMG 232 Chemical Name: 2 [(3R,5R,6S) 5 (3 chlorophenyl) 6 (4
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