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InChiKey: HEAIGWIZTYAQTC-UHFFFAOYSA-N
is a novel potent and selective inhibitor of secreted frizzled-related protein-1 (sFRP-1) with an IC50 ~ 0
83 mg/mL (55
suppresses medial artery calcification
12(5):676-86
A-740003 n L-pyroglutamic Acid InChiKey: HEAIGWIZTYAQTC-UHFFFAOYSA-NA 740003 is a potent, selective and competitive antagonist of P2X7 receptor with IC50 of 18 nM and 40 nM for rat and human P2X7 receptors, respectively. A 740003 potently blocks agonist evoked IL 1 release and pore formation with IC50 of 156 nM and 92 nM in differentiated human THP 1 cells. Product information CAS Number: 861393 28 4 Molecular Weight: 474. 55 Formula: C26H30N6O3 Synonym: A 740003 A740003 Chemical Name: N [1 [[(Cyanoamino)(5