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Fisogatinib
PubMed Central PMCID: PMC3930145
InChiKey: MSYMKEYWUWVZQY-RMKNXTFCSA-N
Epub 2015 Oct 5
Smiles: CC1C=CC(=CC=1)C(=O)C1=CC(=CC(Br)=C1OCC)C(=O)NC1C=CC(=CC=1)C(O)=O
NVP-CGM097 piride Hydrochloride FisogatinibCGM097 is an orally bioavailable HDM2 (human homolog of double minute 2) antagonist with potential antineoplastic activity. Upon oral administration, p53 HDM2 interaction inhibitor CGM097 inhibits the binding of the HDM2 protein to the transcriptional activation domain of the tumor suppressor protein p53. By preventing this HDM2 p53 interaction, the proteosome mediated enzymatic degradation of p53 is inhibited, which may result in the restoration of
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