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J Clin Invest
Chemical Name: 1-(2-Ethylphenoxy)-3-[[(1S)-1
2013 Nov 15
Sir Two Inhibitor Naphthol
(2009) Cell Stem Cell 4(1)
MG-132 463518 J Clin InvestMG132 is a specific, potent, reversible, and cell permeable proteasome inhibitor (Ki = 4 nM) . It reduces the degradation of ubiquitin conjugated proteins in mammalian cells and permeable strains of yeast by the 26S complex without affecting its ATPase or isopeptidase activities. MG132 activates c Jun N terminal kinase (JNK1), which initiates apoptosis. MG132 also inhibits NF B activation with an IC50 of 3 M and prevents secretase cleavage. MG 132
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