I believe that WotC's current financial results strongly suggest that the overall answer is No. Yet I also believe that we cant think about Magic as a single game (as it was 30 years ago): modern MTG is more like a collection of different games that happen to share game pieces, and some of those games are more welcoming to new pieces than others
Interaction should be reserved for critical win attempts or board-dominating threats
Illustrated by Kev Walker Standard Not Legal Alchemy Not Legal Pioneer Not Legal Historic Legal Modern Legal Brawl Legal Legacy Legal Comp
MARK ZUCKERBERG BASEBALL CARD GOING UP FOR AUCTION While these cards are not legally playable in most formats, they remain highly sought-after collectors' items, notes the website
The first idea I had was an insect and rot set that used Grist, the Hunger Tide as commander
Its difficult to even summarize that, never mind condensing the entire mainline 16 games into a single, cohesive card game release