CP-466722 Size:Solid 10 mg Brefeldin A is a fungal

Brefeldin A is a fungal metabolite

Formula: C23H30Cl3N5O3

Vassina EM

Smiles: CC1C=CC(=CC=1)C(=O)NCCCCCC(=O)NC1=CC=CC=C1N

HCT116 cells are pre-treated with the PTEN inhibitor SF-1670 (2 μM) for 24 h (untreated HCT116 cells served as control)

CP-466722 Size:Solid 10 mg Brefeldin A is a fungalCP 466722 is an ATM inhibitor. CP466722 inhibited cellular ATM dependent phosphorylation events and disruption of ATM function resulted in characteristic cell cycle checkpoint defects. Inhibition of cellular ATM kinase activity was rapidly and completely reversed by removing CP466722. Interestingly, clonogenic survival assays showed that transient inhibition of ATM is sufficient to sensitize cells to IR and suggests that therapeutic radiosensitization