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You should seek to combine multiple discard triggers from cards like Key to the City, and Ghostly Pilferer to wrack up the trigger count

I actually made a video on the topic, which you can check out, but here are my rankings

Eldrazi Winter

That way, every card acts as an invitation to learn more about the game it references

TCGPlayer currently doesn't have an average market value, but they do have Isabela's card, 224/204, showing a listed price of $280.89

As with several designs in the first Alchemy set, it's possible this could be attempted in paper, but taken together with other tracking designs, there's a concern of things being overwhelming for tabletop compared to tracking in digital