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Tumor growth is significantly inhibited compared with the control group
2017 Aug 1
It could be useful chemical probe to study HDAC biology
Koumaras B
Reduces Tumor Growth and Metastatic Dissemination in Breast Cancer
NVP-ADW742 Catalog No.:M7898-10 Tumor growth is significantly inhibitedNVP ADW742, also known as ADW 742 or GSK 552602A, is a novel small weight molecular inhibitor of IGF IR with potential anticancer activity. NVP ADW742 inhibited IGF IR mediated proliferation with an IC50 of 11. 12 mol l. NVP ADW742 induced early suppression of Akt, P38 and GSK 3 phosphorylation. NVP ADW742 enhanced the chemosensitivity of Daoy to temozolomide in vitro, as a potent anti tumor agent highly selective against IGF IR. NVP ADW742 was found
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