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PubMed Central PMCID: PMC4315073
Molecular Weight: 821
262 and 3700 nM for FGFR
Chemical Name: 4-{[(2E)-5-hydroxy-3
CAS Number: 135383-60-7
Anle138b 57-9352) PubMed Central PMCID: PMC4315073Anle138b, an oligomeric aggregation inhibitor, blocks the formation of pathological aggregates of prion protein (PrPSc) and of synuclein ( syn). Anle138b strongly inhibits oligomer accumulation, neuronal degeneration, and disease progression in vivo. Anle138b has low toxicity and an excellent oral bioavailability and blood brain barrier penetration. Anle138b blocks A channels and rescues disease phenotypes in a mouse model for amyloid pathology.
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