MS049 dihydrochloride Catalog No.:M14273-2 Smiles: CC1N=CSC=1C1C=CC(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)COCCOCCOCCOC2C=CC(=CC=2)C2=CC3=C(NC4=CC(Cl)=C(C=C4)OCC4C=CC=C(F)C=4)N=CN=C3C=C2)C(C)(C)C)=CC=1

Smiles: CC1N=CSC=1C1C=CC(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)COCCOCCOCCOC2C=CC(=CC=2)C2=CC3=C(NC4=CC(Cl)=C(C=C4)OCC4C=CC=C(F)C=4)N=CN=C3C=C2)C(C)(C)C)=CC=1

and >100 μM

50 or 100 μg/L)

TAS4464 shows prolonged target inhibition in human tumor xenograft mouse models

homeostasis

MS049 dihydrochloride Catalog No.:M14273-2 Smiles: CC1N=CSC=1C1C=CC(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)COCCOCCOCCOC2C=CC(=CC=2)C2=CC3=C(NC4=CC(Cl)=C(C=C4)OCC4C=CC=C(F)C=4)N=CN=C3C=C2)C(C)(C)C)=CC=1MS049 dihydrochloride is a potent, selective, and cell active dual inhibitor of PRMT4 and PRMT6 with IC50s of 34 nM and 43 nM, respectively. MS049 dihydrochloride reduces levels of Med12me2a and H3R2me2a in HEK293 cells. MS049 dihydrochloride is not toxic and does not affect the growth of HEK293 cells. Product information CAS Number: 2095432 59 8 Molecular Weight: 321. 29 Formula: C15H26Cl2N2O Chemical Name: bis(chlorohydrogen); {2 [4