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XE991 2HCl 444217 Discovery of chemical inhibitors of

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Description

Discovery of chemical inhibitors of the selective transfer of lipids mediated by the HDL receptorSR-BI

is a protective agent against apoptosis

Asian Pac J Allergy Immunol

9 μM in complete media) and is much more potent under low glucose conditions with an IC50 of 7

2334/josnusd

XE991 2HCl 444217 Discovery of chemical inhibitors ofXE991 2HCl is a potent and selective blocker of KV7 (KCNQ) voltage gated potassium channels which blocks KV7. 2+7. 3 (KCNQ2+3) M currents (IC50 = 0. 6 0. 98 M) and KV7. 1 (KCNQ1) homomeric channels (IC50 = 0. 75 M) but is less potent against KV7. 1 minK channels (IC50 = 11. 1 M). Product information CAS Number: 122955 13 9 Molecular Weight: 449. 37 Formula: C26H22Cl2N2O Chemical Name: 10,10 bis(4 pyridinylmethyl) 9(10H) anthracenone, dihydrochloride

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