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It inhibits histone demethylase JMJD3
27(40):5315-25
Strategies and Advancement in Antibody-Drug Conjugate Optimization for Targeted CancerTherapeutics
STO-609 is highly selective for CaM-KK without any significant effect on the downstream CaM kinases (CaM-KI and -IV)
Selective small molecule compounds increase BMP-2 responsiveness by inhibiting Smurf1-mediated Smad1/5 degradation
Wnt-C59 - Wnt Antagonist. CAS# 1243243-89-1 size:10mg solid It inhibits histone demethylase JMJD3Wnt C59, CAS No. 1243243 89 1, is a very potent and highly selective Wnt signaling antagonist with an IC50 ~ 74 pM in the Wnt signaling reporter assay. It prevents palmitylation of Wnt proteins by Porcupine (a membrane bound O acyltransferase), thereby blocking Wnt protein secretion and activity. Wnt C59 displayed good bioavailability as once daily oral administration and blocked progression of mammary tumors in MMTV WNT1 transgenic mice model while
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