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PubMed PMID: 24845199
1'-biphenyl]-4-ylmethyl)-6-phenyl-3-(pyridin-2-yl)-1
that selectively binds to CBFβ-SMMHC and disrupts its binding to RUNX1
ML323 inhibits the deubiquitination of PCNA and FANCD2
Formula: C22H20N4OS2
ITD-1 - TGFβ inhibitor. CAS# 1099644-42-4 0281 PubMed PMID: 24845199ITD 1, CAS No. 1099644 42 4, is a novel and highly selective TGF pathway inhibitor identified by a high throughput, embryonic stem cell (ESC) cardiac differentiation screening. ITD 1 promoted cardiomyocyte differentiation specifically via degradation of the TGF type II receptor (TGFBR2), effectively clearing the receptor from the cell surface and selectively inhibiting intracellular signaling (IC50 0. 40. 8 M), revealing a role for TGF signaling