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10-trien-1-yl]sulfanyl}propanoic acid
Smiles: CN(C)S(=O)(=O)C1=CC=C(C=C1)NC(=S)N1CCC(CC1)C(O)(C1C=CC=CC=1)C1C=CC=CC=1
dose-dependent exposure and modulation of the pharmacodynamic marker p-ERK is observed in the xenografts
InChi: InChI=1S/C27H24N2O9/c30-26(38-21-5-3-20(4-6-21)29(32)33)28-11-9-17(10-12-28)27(31
2006 Jan 6
NVS-CECR2-1 rlukast 10-trien-1-yl]sulfanyl}propanoic acidNVS CECR2 1, a non BET family Bromodomain (BRD) inhibitor, is a potent and selective cat eye syndrome chromosome region, candidate 2 (CECR2) inhibitor. NVS CECR2 1 binds to CECR2 BRD with high affinity (IC50=47 nM; KD=80 nM). NVS CECR2 1 exhibits cytotoxic activity and induces apoptosis against various cancer cells by targeting CECR2 as well as via CECR2 independent mechanism. Product information CAS Number: 1992047 61 6 Molecular Weight: 495. 68
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