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A83-01 --- an ALK inhibibitor
Chemical Name: N-[2-(4-{3-[(propan-2-yl)amino]pyridin-2-yl}piperazine-1-carbonyl)-1H-indol-5-yl]methanesulfonamide
2020 Aug 10
induce differentiation and apoptosis in a malignant glioma cell line (A-172) and an esophageal cancer cell line (Eca-109)
this effect is dose-dependently inhibited by Mitochonic acid 5 treatment
Esculentoside A Catalog No.:M14898-10 A83-01 --- an ALK inhibibitorEsculentoside A (EsA), a kind of triterpene saponin isolated from roots of Phytolacca esculenta. Esculentoside A (EsA) possesses anti inflammatory activity in acute and chronic experimental models, has selective inhibitory activity towards cyclooxygenase 2 (COX 2). Esculentoside A (EsA) suppresses inflammatory responses in LPS induced acute lung injury (ALI) through inhibition of the nuclear factor kappa B (NF B) and mitogen activated protein kinase