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In Vitro Activity of Cefepime/AAI101 and Comparators against Cefepime Non-susceptible Enterobacteriaceae
Activin receptor-like kinase5 inhibition suppresses mouse melanoma by ubiquitin degradation of Smad4
InChiKey: SWMDAPWAQQTBOG-UHFFFAOYSA-N
2-benzothiazin-4-yl}oxy)ethyl carbonate
Jan-Feb 1985
LY2606368 - CAS# 1234015-52-1 ine maleate In Vitro Activity of Cefepime/AAI101Prexasertib, also know LY2606368, is a n inhibitor of checkpoint kinase 1 (chk1) with potential antineoplastic activity. Upon administration, LY2606368 selectively binds to chk1, thereby preventing activity of chk1 and abrogating the repair of damaged DNA. This may lead to an accumulation of damaged DNA and may promote genomic instability and apoptosis. LY2606368 may potentiate the cytotoxicity of DNA damaging agents and reverse tumor cell resistance
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