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small-molecule Polo-like kinase 1 (PLK1) inhibitor with potential antineoplastic activity
It inhibits the growth of a variety of human cancer cell lines with IC50 ranging from 60 to 200 nM
6-dihydropyrimido[4'
Chemical Name: N-(4-((2-(cyclopropanecarboxamido)pyridin-4-yl)oxy)-2
The overexpression of KDM4A/KDM4B in prostate cancer and their association with androgen receptor suggest that KDM4A/KDM4B are potential progression factors for prostate cancer
Topiramate 000067 small-molecule Polo-like kinase 1 (PLK1)Topiramate (brand name Topamax) is an anticonvulsant (antiepilepsy) drug. In late 2012, topiramate was approved by the United States Food and Drug Administration (FDA) in combination with phentermine for weight loss. The drug had previously been used off label for this purpose. Topiramate is used to treat epilepsy in children and adults, and it was originally used as an anticonvulsant. In children, it is indicated for the treatment of Lennox Gastaut