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Nielsen EØ
small molecules similar to TCS PIM-1 1 may serve as useful starting scaffolds for the development of other improved yet selective Pim-1 inhibitors
based on pharmacokinetic experiments
Cetkovic-Cvrlje M
PMID: 29518481
LY-303511 - CAS# 154447-38-8 Catalog No.:M6665-10 Nielsen EØLY 303511, CAS No. 154447 38 8, also known as NV 128 and EM 101, is a potent mTOR inhibitor. LY 303511 enhances TRAIL sensitivity of SHEP 1 neuroblastoma cells via hydrogen peroxide mediated mitogen activated protein kinase activation and up regulation of death receptors. LY 303511 amplifies TRAIL induced apoptosis in tumor cells by enhancing DR5 oligomerization, DISC assembly, and mitochondrial permeabilization. LY 303511 acts via
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