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In primary cultures of rat cerebral cortex neurons
Pomalidomide4alkylC4acid
The imidazopyridine derivative JK184 reveals dual roles for microtubules in Hedgehog signaling
In FLT3-WT-bearing RS4-11 cells and FLT3-ITD-harboring MV4-11 and Molm-14 cells
InChiKey: XCIGZBVOUQVIPI-UHFFFAOYSA-N
LY3009120 Catalog No.:M8369-2 In primary cultures of ratLY3009120, also known as DP 4978, is potent and selective pan RAF inhibitor with potential anticancer activity. LY3009120 showed activities against BRaf or Ras mutant tumor cells . LY3009120 binds to ARaf, BRaf and CRaf isoforms with similar affinity in cells with activating mutations of BRaf or KRas. LY3009120 induces minimal paradoxical pathway activation in NRas or KRas mutant cells. LY3009120 inhibits MEK phosphorylation and cell proliferation in
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