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To define the in vivo potency of PF-AKT400 (Compound 42) in the PC3 xenograft model
and 150 nM
Datelliptium acetate is selectively cytotoxic for solid tumors over leukemia L1210
CAS Number: 207306-50-1
Chemical Name: (18S)-18-[(dimethylamino)methyl]-17-oxa-4
SC-10914 pferol 3-O-gentiobioside To define the in vivoSC10914 is a highly potent PARP inhibitor (PARP1 IC50 = 7. 87 nM) with potent anti proliferative activity against human BRCA deficient tumor cells (MDA MB 436, BRCA1 deficient, IC50 = 4. 03 nM, Capan 1 BRCA2 deficient, IC50 = 11. 66 nM) and PTEN deficient tumor cells (HGC 27, PTEN deficient, IC50 = 0. 35 M). SC10914 showed potent anti tumor activity in BRCA1 2 mutant tumor models and better pharmacokinetics profile has the potential to be selected as
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