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PD153035 causes a dose-dependent growth inhibition of EGF receptor-positive cell lines
a new class of potential cancer therapeutics
Smiles: O=C(NCC1C=CN=CC=1)[C@]12C[C@@]3(C[C@H](C1)C[C@@H](C3)C2)C1C=CC(Cl)=CC=1
0 μM for A498
in cells transfected with the empty plasmid which has no CYP1B1 gene and therefore cannot express CYP1B1 protein
Vinflunine tartrate Ivabradine Hydrochloride PD153035 causes a dose-dependent growthVinflunine is a bi fluorinated derivative of the semi synthetic vinca alkaloid vinorelbine with antitubulin, antineoplastic, and antiangiogenic activities. Vinflunine inhibits tubulin assembly without any stablization of assembled microtubules at concentrations comparable to those of other vinca alkaloids such as vincristine, vinblastine and vinorelbine; this effect on microtubule dynamics results in cell cycle arrest in mitosis and apoptosis.
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