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2012 Jan 1
SAR407899 (3 μM) completely blocks thrombin-induced shrinkage of human umbilical vein endothelial cells (HUVECs) and stress fiber formation
24-hexamethyl-1
Solubility: DMSO : ≥ 100 mg/mL (324
suppresses lung cancer cell proliferation and inhibits tumor growth in vivo
HTH-01-015 - CAS# 1613724-42-7 Catalog No.:M6435-10 2012 Jan 1HTH 01 015, CAS No. 1613724 42 7, is a potent and selective inhibitor of NUAK1 (IC50 = 100 nM) and does not affect the activity of a panel of 139 other kinases, including additional AMPK family members. The administration of HTH 01 015 to MEFs (mouse embryonic fibroblasts) significantly inhibits migration in a wound healing assay to a similar extent as NUAK1 knockout. HTH 01 015 also inhibit proliferation of MEFs to the same extent as NUAK1 knockout
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