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O-desmethyl gefitinib inhibits EGFR with an IC50 of 36 nM in subcellular assays
4-dimethyl-1H-1
17)/p+1/t7-
13-diazatetracyclo[7
Smiles: CN(C)NC(=O)CCC(O)=O
ARQ 621 Catalog No.:M19604-C O-desmethyl gefitinib inhibits EGFR withARQ 621 is an allosteric, potent and selective inhibitor of Eg5, a microtubule based ATPase motor protein involved in cell division. Anti tumor activity. ARQ 621 is a kinesin inhibitor. Product information CAS Number: 1095253 39 6 Molecular Weight: 552. 43 Formula: C28H24Cl2FN5O2 Chemical Name: N (3 aminopropyl) 3 chloro N [(1R) 1 [7 chloro 4 oxo 3 (phenylamino) 3,4 dihydroquinazolin 2 yl]but 3 yn 1 yl] 2 fluorobenzamide Smiles:
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